+1.7 tears, +0.3 speed, reduces damage.
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
Pay to Play
This item turns all doors that require a key into doors which need a coin to enter instead. This affects shops, item rooms, libraries and other key doors.
Increases damage and speed. Upon entering a room adjacent to a secret room, a howl sound effect will play.
Increases damage, but also increases the chance of champion enemies appearing.
Spawns an orbiting eye familiar that fires tears every 2 seconds.
While firing, Isaac gains a green aura that poisons nearby enemies.
A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.
???'s Only Friend
Summons a big attack fly that can be controlled with the shooting direction-keys.
Isaac's tears split in two when they hit something.
A Familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting.
An Angel Room door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Suture becomes attached to Isaac, and does touch damage to enemies within its attacking range.
A familiar that damages enemies by chasing them as well as inducing the fear effect.
Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.
Allows Isaac to hold 1 additional trinket.
A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.
+5 range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room.
Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes.