Item: Portable Slot
Dead Sea Scrolls
Triggers the effect of a random activated item from a list of possible options (not every activated item is included).
Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room.
Shoots 8 tears around Isaac, which retain the damage, shot speed, and special effects of his tears. Each tear shot by Isaac increases item charge by one.
Upon use, sacrifices up to 2 familiars and spawns an item from the Devil Room Pool for each familiar sacrificed.
Summons a random familiar for the current room. Can summon familiars not yet unlocked.
When used, places an explosive TNT barrel that can be pushed and used to destroy rocks or damage enemies. If used a second time in the same room while the previous TNT barrel is still intact, it will remotely explode the TNT.
Book of the Dead
Upon use, spawns a charmed Bony or an orbital bone for each enemy killed in the current room.
When used, Mom's Box will drop a random trinket on the ground. While held, increases luck by 1 and doubles the effects of trinkets.
Passively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies while also casting the effect of Crack the Sky.
Upon activation, 1 coin will be consumed, and a random pickup may drop, similar to the slot machine.
Reveals the map (except the Super Secret Room) and drops a random Tarot Card or soul heart.
Upon use, Isaac farts, charming all nearby enemies.
Spawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in The Dark Room.
Mom's Bottle of Pills
Gives Isaac a random pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.
While held, causes multiple Mom's Foots to come down and stomp on Isaac. One of two parts necessary to create Mom's Shovel.
Bombs you place explode only when you use this item. Gives 5 bombs.
Grants a random item effect for the current room.
Upon use, Isaac fires a laser similar to the one used by Mega Satan. This laser deals massive damage, lasts for approximately 15 seconds, and persists between rooms. Isaac is pushed backwards by the force of the laser while it is active.