Item: Punching Bag
Increases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.
While firing, Isaac gains a green aura that poisons nearby enemies.
Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.
Isaac can hold 2 cards at once and all pills are replaced by cards.
Cain's Other Eye
Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeperand shoots normal tears in the same direction as Isaac.
Pay to Play
This item turns all doors that require a key into doors which need a coin to enter instead. This affects shops, item rooms, libraries and other key doors.
Grants one Heart Container and gives 2 Soul Hearts.
Increases the size of blue spiders and Blue Flies and doubles the amount of damage they deal.
Reveals all special rooms (except secret rooms of any kind).
Grants a random Harbinger familiar that changes every 10 seconds.
Increases damage. Adds a chance to fire acidic tears which can destroy obstacles.
Destroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.
Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
Charm of the Vampire
Heals the character for half of a red heart for every 13 monsters killed.
Reveals and opens all Secret Room and Super Secret Room entrances.
Key Piece 1
Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Doubles damage, halves tears stat, and greatly reduces shot speed.