Item: Pupula Duplex
Grants Isaac one red heart container and fully restores Isaac's health.
Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
While firing, Isaac gains a green aura that poisons nearby enemies.
Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals.
A trail of blue creep is left behind Isaac, which damages enemies.
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
Grants the player one red heart container, one soul heart, and one black heart.
A Familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting.
Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Money = Power
Increases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.
Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.
Drops a random card or rune. Doubles the effects of cards and runes.
Chance to block projectiles coming from any direction.
A white orbiting fly which deals 3 contact damage per tick to enemies. This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone.
Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills".
Increases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.