Increases the size of blue spiders and Blue Flies and doubles the amount of damage they deal.
An Angel Room door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Magic 8 Ball
Increases Shot Speed, and drops a Tarot Card when picked up.
Chance to block projectiles coming from any direction.
Daddy Long Legs' shadow follows Isaac and stomps on enemies.
Randomly increases and decreases some of the character's stats. There will always be at least one stat increase and one decrease and the same stats can be increased/decreased multiple times.
Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup.
Causes shops to instantly restock their items when they are bought. Granted by default for every character in Greed Mode.
+1 luck. Spawns a fairy familiar that points out secret room entrances and tinted rocks.
Circle of Protection
Surrounds Isaac with a large white halo around him that pulsates. With each pulse, the halo deals contact damage to enemies equal to Isaac's damage. Each pulse also converts any enemy shots touching the ring into friendly purple homing tears.
Chaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor.
Lord of the Pit
Grants flight and increases speed.
Sack of Pennies
Isaac is followed by a small bag that drops a coin every 2 rooms.
A trail of blue creep is left behind Isaac, which damages enemies.
Replaces tears with a piercing laser with unlimited range.
Grants one bone heart and spawns three red heart pickups.
A portable beggar who follows Isaac, picks up coins for himself, and occasionally drops a pickupafter collecting a coin. Does not spawn collectibles.