Spawns a finger familiar that points at enemies, dealing constant damage.
Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
A familiar who will drop a half red heart every 2 rooms.
Follows Isaac around shooting normal tears.
The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death.
Buddy in a Box
Grants a familiar with a random tear effect. The familiar is randomized at the start of each floor.
Spawns a familiar that slowly charges forward and damages enemies in its path.
Grants a random Harbinger familiar that changes every 10 seconds.
Tears bounce off walls, enemies, and environmental objects.
Spawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep.
Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Grants a soul heart. Adds a chance to block enemy shots.
Gives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Grants poison tears, which deal damage over time when inflicted.
Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals.
Increases damage by 1 and range by 5 for tears fired from the left eye.