Increases damage and increases the chance for a Devil or Angel Room to appear.
Increases speed and reduces character size. Also gives a random pill.
Doubles damage, halves tears stat, and greatly reduces shot speed.
Ball of Bandages
Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.
Tears have a chance to charm enemies.
A trail of blue creep is left behind Isaac, which damages enemies.
When Isaac receives damage, the bottle breaks and a puddle of blue creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room.
Grants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room.
-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.
Allows Isaac to hold 1 additional trinket.
Increases Speed and Shot Height and decreases Isaac's size, but lowers Range.
Grants the player one red heart container, one soul heart, and one black heart.
While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
While firing tears, Isaac has a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac. The eye will be destroyed if it comes into contact with an enemy or obstacle.
Bucket of Lard
Grants two empty heart containers and heals Isaac by half a heart, but decreases speed by 0.2.
Gives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
Increases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.