Item: Roid Rage
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
Eye of Belial
Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
Chance to block projectiles coming from any direction.
The Ludovico Technique
Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Money = Power
Increases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.
Grants Isaac a permanent 50% chance to respawn with 1/2 of a red heart after death.
Curse of the Tower
Causes Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic.
Isaac's tears gain a random effect that changes every shot.
Spawns a bone familiar that can be aimed with the fire buttons and does contact damage.
Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
Follows Isaac around, shooting enemies with an eye laser similar to Technology.
Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
Grants an active item charge every 15 enemies killed.
Spawns a familiar that will follow Isaac's movements on a 2.5 second delay. Tears that pass through the baby will be doubled and increase in speed.
Whenever Isaac takes damage, a black ring briefly appears around Isaac, dealing damage to all nearby enemies.
All standard bomb pickups become 1+1 bomb pickups.