Item: Rotten Baby
Drops a random card or rune. Doubles the effects of cards and runes.
Increases speed and reduces character size. Also gives a random pill.
Increases speed by +0.2 and grants piercing tears.
Tears are replaced with piercing white blasts of light.
Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
Makes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.
Shard of Glass
Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Greatly increases the chance to find sacks.
Adds a chance to shoot fear tears and decreases tear delay by 1.
Sack of Pennies
Isaac is followed by a small bag that drops a coin every 2 rooms.
Randomizes all passive items upon pickup and at the start of each succeeding floor.
Whore of Babylon
Increases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.
Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Isaac has a random chance to fire a Holy tear, which, when it hits an enemy, will spawn a Crack the Sky-style light beam on the same enemy, dealing damage.
Adds a chance to shoot a fire that damages enemies and remains in place until it deals enough damage or the room is left.
There will be 2 items available to choose from after defeating a boss. Choosing 1 item causes the other to disappear.