Item: Rubber Cement
A familiar that charges forward and deals touch damage to any enemies in its path.
Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Grants Isaac one full red heart container.
Spawns a familiar that follows Isaac around and fires spectral tears.
Adds 3 black hearts and increases Damage by 1.
Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.
Spawns a familiar that follows Isaac around and fires homing tears.
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
Tears fired from left eye do increased damage.
Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.
Gives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny.
Contract From Below
Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.
Spawns a friendly familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one.
A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.
Isaac emits a beam from his face. Isaac's tears travel in the path of the beam.
Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier.
Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. In the burst of tears is a kidney stone which deals a lot of damage.
Buddy in a Box
Grants a familiar with a random tear effect. The familiar is randomized at the start of each floor.