Item: Rune Bag
Tears up, adds 1 soul heart, and decreases Isaac's size.
Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.
Spawns an orbiting eye familiar that fires tears every 2 seconds.
Enemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin.
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.
When hit, spawns up to 2 blue spiders.
Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Range up and makes shot tears revolve around Isaac until they drop.
Spawns a finger familiar that points at enemies, dealing constant damage.
A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
Dark Prince's Crown
Increases range, tears, and shot speed when at exactly one red heart.
Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.
Crown of Light
Gives Isaac a crown that glows blue when active, and turns gray when inactive. While Isaac has no empty red heart containers, Isaac's tears are replaced with blue diamond tears that deal double damage. Regardless of health, the crown will deactivate for the current room when Isaac takes damage.
Zodiac will give Isaac a random zodiac item effect that changes after every floor.
Increases damage, and adds 1 heart container.
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
Spawns an egg familiar, which cracks and turns into a random charmed enemy when Isaac is hurt. The egg regenerates upon entering a different room.