Item: ???'s Only Friend
Grants a soul heart. Adds a chance to block enemy shots.
Activated Items can be "overcharged" to allow for an additional use.
Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies.
Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. In the burst of tears is a kidney stone which deals a lot of damage.
Magic 8 Ball
Increases Shot Speed, and drops a Tarot Card when picked up.
Reveals all rooms for every floor. However, it does not reveal icons or secret rooms.
Halo of Flies
Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Ball of Tar
Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
This item will boost one of Isaac's stats depending on the color of the aura around him. The aura will disappear upon taking damage and will reappear with a random color upon entering a new room. A red aura boosts damage, a blue aura boosts rate of fire, a yellow aura boosts speed, and an orange aura boosts range.
Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Reduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Grants Isaac a permanent 50% chance to respawn with 1/2 of a red heart after death.
A portable beggar who follows Isaac, picks up coins for himself, and occasionally drops a pickupafter collecting a coin. Does not spawn collectibles.
A familiar that follows Isaac and blocks tears. If a tear hits Farting Baby, there is a high chance for it to fart, which will either knock back, poison, or charm all nearby enemies.
Grants 2 Heart Containers and completely restores health.