Item: Sack of Pennies
Familiar that follows Isaac, leaving blood creep on the ground.
A glass of milk follows Isaac and spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the rest of the room.
Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Magic 8 Ball
Increases Shot Speed, and drops a Tarot Card when picked up.
Spawns a fly familiar that orbits around a random enemy and deals 5 damage per tick to enemies it comes in contact with.
Whore of Babylon
Increases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.
Grants one bone heart and spawns three red heart pickups.
Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Boom Fliesdamaging enemies it passes through.
A Loki familiar that follows Isaac and shoots 4 tears in a cross pattern.
Has a chance to drop a random pickup when Isaac takes damage.
Increases Luck by 1, grants 1 Soul Heart and spawns 2 Keys.
An Angel Room door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
A familiar that follows Isaac around shooting blood tears.
Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.
Increases Damage and Speed, plus adds one Soul Heart.
Chance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up.
Spawns 2 keys. Generates additional pickups from chests.
Grants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room.
Allows Isaac to hold 1 additional trinket.