Gives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
Spawns a familiar that follows Isaac around and fires homing tears.
Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Gives one extra pickup (1+1 Free version) of Red Hearts, pennies, bombs, and keys. Does not work with blue, black, and half red hearts, nickels, and dimes.
When Isaac receives damage, the bottle breaks and a puddle of blue creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room.
Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes.
Spirit of the Night
Grants spectral tears and flight.
Grants the player one red heart container, one soul heart, and one black heart.
Increases Damage and Speed, plus adds one Soul Heart.
Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.
Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Gives 5 bombs and grants all bombs poison effect.
Gives Isaac a golden censer familiar which creates a huge aura of light that slows down any enemies and enemy shots inside it.
Whenever Isaac takes damage, a black ring briefly appears around Isaac, dealing damage to all nearby enemies.
Dagger orbits Isaac, dealing very high damage.
Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Ball of Bandages
Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.
Drops a random card or rune. Doubles the effects of cards and runes.