Item: Samson's Chains
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
Spawns a familiar that follows Isaac around and has a chance to drop a heart, coin, bomb, or keyafter clearing a room.
Dad's Lost Coin
Increases range by 1.5. Drops a lucky penny.
A familiar that mirrors the player's movements and shoots in the opposite direction.
Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Every tear has a small shield which will allow it to block one enemy projectile.
Grants charged tears that deal greater damage when fully charged.
Reduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.
Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.
Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
Increases damage, but also increases the chance of champion enemies appearing.
Increases Shot Speed and damage.
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
A glass of milk follows Isaac and spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the rest of the room.
Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
Increases speed by +0.2 and grants piercing tears.
Isaac can hold 2 pills at once and all cards are replaced by pills.
Two items spawn in every Treasure Room. Only one can be taken; the other will disappear.
Crown of Light
Gives Isaac a crown that glows blue when active, and turns gray when inactive. While Isaac has no empty red heart containers, Isaac's tears are replaced with blue diamond tears that deal double damage. Regardless of health, the crown will deactivate for the current room when Isaac takes damage.