Buddy in a Box
Grants a familiar with a random tear effect. The familiar is randomized at the start of each floor.
Follows Isaac and automatically fires at enemies in its reach.
Gives a random chance for projectiles to fire in all 4 cardinal directions.
+0.7 tears up. Grants a random item at the start of the next run.
Ball of Bandages
Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.
Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.
Increases damage. Adds a chance to fire acidic tears which can destroy obstacles.
Increases damage and increases the chance for a Devil or Angel Room to appear.
Adds a chance to shoot concussive tears, causing enemies to walk around randomly.
While firing tears, Isaac has a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac. The eye will be destroyed if it comes into contact with an enemy or obstacle.
Isaac's head is removed from his body and floats around him. Increases Damage by 1 and grants -1 Tear Delay.
Dagger orbits Isaac, dealing very high damage.
+1.25 Range Up. +0.5 Tear Height. +1 Luck Up.
Grants a familiar that transforms into another random familiar every 10 seconds.
Curse of the Tower
Causes Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic.
Grants a random Harbinger familiar that changes every 10 seconds.
Dark Prince's Crown
Increases range, tears, and shot speed when at exactly one red heart.