Item: Sharp Plug
Reveals all special rooms (except secret rooms of any kind).
Sack of Sacks
Spawns a sack familiar that has a chance to drop a sack upon clearing a room.
Increases damage by a flat 0.1 and grants a soul heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.
A familiar that follows Isaac around shooting blood tears.
Increases the size of blue spiders and Blue Flies and doubles the amount of damage they deal.
Familiar that follows Isaac, leaving blood creep on the ground.
Spawns a familiar that slowly charges forward and damages enemies in its path.
Increases damage and range while reducing tears and shot speed. Grants homing tears and tears gain a damaging halo.
Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
Grants quadruple shot but decreases tears.
Upon dying, resurrect as Revived Lazarus with one heart container and Anemic item.
Grants a soul heart. Adds a chance to block enemy shots.
-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.
Grants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.
Follows Isaac around shooting normal tears.
Randomly increases and decreases some of the character's stats. There will always be at least one stat increase and one decrease and the same stats can be increased/decreased multiple times.
Maw of the Void
+1.0 Damage Up. After continuously firing tears for 2.5 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring that rapidly deals damage equal to Isaac's tear damage to any enemies in contact with it.
While firing, Isaac gains a green aura that poisons nearby enemies.