Item: Shoop Da Whoop!
Upon activation, 1 coin will be consumed, and a random pickup may drop, similar to the slot machine.
Book of Revelations
Adds 1 soul heart, increases the chance for a Devilor Angel Room to appear, and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom).
If the box is empty, picks up all items and pickups in a room and stores them. If the box is not empty, places all stored items and pickups in the current room.
Spawns a blue spider or fly. Turns pickups in the room into blue spiders or flies.
Upon activation, Isaac loses a half-heart (one whole heart in The Womb onwards) for a random amount of coins, similar to the blood donation machine.
Spawns a stationary fly familiar that fires tears at nearby enemies.
Upon use, sacrifices up to 2 familiars and spawns an item from the Devil Room Pool for each familiar sacrificed.
While held, causes multiple Mom's Foots to come down and stomp on Isaac. One of two parts necessary to create Mom's Shovel.
Freezes all enemies until a fire button is pressed.
Upon use, spawns certain pickups or itemsdepending on the floor it is used on. Single-use.
Consumes all pedestal items in the room. Active items will have their effects added to Void, and passive items will grant stat upgrades.
Dead Sea Scrolls
Triggers the effect of a random activated item from a list of possible options (not every activated item is included).
Changes all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.
Removes one red heart container in exchange for gaining 3 Soul Hearts.
Displaces enemy sprites for the current room and increases or decreases a random stat.
Bob's Rotten Head
Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.