Item: Sinus Infection
This item will boost one of Isaac's stats depending on the color of the aura around him. The aura will disappear upon taking damage and will reappear with a random color upon entering a new room. A red aura boosts damage, a blue aura boosts rate of fire, a yellow aura boosts speed, and an orange aura boosts range.
Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.
Grants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms.
Spawns a chest familiar that follows Isaac and drops a random pickup every few rooms.
Daddy Long Legs' shadow follows Isaac and stomps on enemies.
While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
An Angel Room door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Zodiac will give Isaac a random zodiac item effect that changes after every floor.
Spawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
The Inner Eye
Grants triple shot but decreases tears.
Isaac's tears split in two when they hit something.
Spawns a cloud familiar that leaves a trail of tears that damages enemies. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
Range up and makes shot tears revolve around Isaac until they drop.
Every tear has a small shield which will allow it to block one enemy projectile.
Grants 2 Heart Containers and completely restores health.