Item: Sissy Longlegs

Increases luck and HP by 1.

Gives Isaac a random tear effect every room.
Removed in Afterbirth: The effect given changes upon entering a room.
Added in Afterbirth: The effect changes every 3 seconds.

Spawns 4 random pills around Isaac.

Grants one bone heart and spawns three red heart pickups.

Increases damage based on how many empty heart containers Isaac has.

Reduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.

Spawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.

Increases Damage by 1.

Increases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.

Upon entering a room with enemies in it, has a chance to spawn a random charmed enemy that persists across rooms.

Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.

Suture becomes attached to Isaac, and does touch damage to enemies within its attacking range.

Increases damage as Isaac receives damage. Damage increase stays for the whole floor.

Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.

Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.

Summons a big attack fly that can be controlled with the shooting direction-keys.

Grants triple shot but decreases tears.

Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.

Randomly increases and decreases some of the character's stats. There will always be at least one stat increase and one decrease and the same stats can be increased/decreased multiple times.

Spawns a familiar that fires clusters of tears. Must be charged before shooting.