When hit, spawns up to 2 blue spiders.
Taking damage releases a ring of 10 high damage tears.
Adds 25 to Isaac's coin count, capping at 99.
Grants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.
Spawns 3 random trinkets. Taking damage has a small chance to swallow Isaac's currently held trinket, gaining its effect permanently.
+0.25 Speed. Running into enemies while at a high speed will deal 18 points of damage. Does not prevent contact damage.
Isaac has a random chance to fire a Holy tear, which, when it hits an enemy, will spawn a Crack the Sky-style light beam on the same enemy, dealing damage.
Prevents curses. Grants one black heart. Increases the chance for a Devil or angel room to appear.
Increases speed by 0.3 and shot speed by 20%.
Follows Isaac and automatically fires at enemies in its reach.
Has a chance to fire tears that inflict bleeding on enemies, causing them to slowly take damage over time.
Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.
8 Inch Nails
+1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.
Sack of Pennies
Isaac is followed by a small bag that drops a coin every 2 rooms.
Range up and makes shot tears revolve around Isaac until they drop.
A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.
Adds an extra life; upon death, it respawns Isaac as Black Judas with only two black hearts.
A Loki familiar that follows Isaac and shoots 4 tears in a cross pattern.