Item: Smart Fly

Spawns a finger familiar that points at enemies, dealing constant damage.

Gives Isaac's tears a boomerang effect, and increases range and shot speed.

Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills".

Gives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.

Grants Isaac a permanent 50% chance to respawn with 1/2 of a red heart after death.

Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.

Surrounds Isaac with a large white halo around him that pulsates. With each pulse, the halo deals contact damage to enemies equal to Isaac's damage. Each pulse also converts any enemy shots touching the ring into friendly purple homing tears.

Adds 1 heart container.

A familiar that damages enemies by chasing them as well as inducing the fear effect.

Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.

Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.

Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.

Grants -1 Tear Delay and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's.

After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.

This item will boost one of Isaac's stats depending on the color of the aura around him. The aura will disappear upon taking damage and will reappear with a random color upon entering a new room. A red aura boosts damage, a blue aura boosts rate of fire, a yellow aura boosts speed, and an orange aura boosts range.

Increases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.

Increases damage by 0.5, and multiplies it by 1.5x.

Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes.

Increases Damage by 1.

Tears have a chance to charm enemies.