Item: Spider Bite
Grants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.
Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the size of the ring.
Increases Luck by 1, grants 1 Soul Heart and spawns 2 Keys.
Maw of the Void
+1.0 Damage Up. After continuously firing tears for 2.5 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring that rapidly deals damage equal to Isaac's tear damage to any enemies in contact with it.
Daddy Long Legs' shadow follows Isaac and stomps on enemies.
Chance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up.
Increases speed and reduces character size. Also gives a random pill.
When Isaac is hit, 1 point of an item's charge is filled.
Contract From Below
Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.
Adds 3 soul hearts. Grants The Wafer effect for the current room upon taking damage.
Adds a chance to fire a gas cloud that damages nearby enemies.
Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, it stops moving.
Sets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again.
Spawns a chest familiar that follows Isaac and drops a random pickup every few rooms.
Grants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room.
Grants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms.
Spawns an egg familiar, which cracks and turns into a random charmed enemy when Isaac is hurt. The egg regenerates upon entering a different room.