Eye of Belial
Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
Upon entering a room with enemies in it, has a chance to spawn a random charmed enemy that persists across rooms.
Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.
Grants one red heart container, restores 5 red hearts, and increases speed by 0.3.
A glass of milk follows Isaac and spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the rest of the room.
Increases range and shot speed, while adding 1 Black Heart.
Gives Isaac's tears a boomerang effect, and increases range and shot speed.
Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
A red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Causes Isaac's activated item to activate twice on each use.
Spawns a familiar that fires clusters of tears. Must be charged before shooting.
Tears up, adds 1 soul heart, and decreases Isaac's size.
Activated Items can be "overcharged" to allow for an additional use.
A Loki familiar that follows Isaac and shoots 4 tears in a cross pattern.
???'s Only Friend
Summons a big attack fly that can be controlled with the shooting direction-keys.
Spawns 2 keys. Generates additional pickups from chests.
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals.