Item: Stem Cells

Grants triple shot but decreases tears.

While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.

Increases damage by 1, increases tears by 0.2, and decreases speed by 0.1.

Increases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.

Increases range by 1.5. Drops a lucky penny.

Grants quadruple shot but decreases tears.

+2.25 Range Up. +1.5 Tear Height. Isaac's tears travel through walls and appear out of the opposite wall. Isaac's tears also travel over rocks and objects.

Spawns a cloud familiar that leaves a trail of tears that damages enemies. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.

Increases range and shot height.

Increases Damage and Speed, plus adds one Soul Heart.

Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier.

Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy.

Increases damage. Adds a chance to fire acidic tears which can destroy obstacles.

Isaac gains a shield that protects him from enemy shots.

Drops a random card or rune. Doubles the effects of cards and runes.

Adds a chance to fire a piercing tear that instantly kills any enemy that it touches.

Dagger orbits Isaac, dealing very high damage.

Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.

Spawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.

Increases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.