Gives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
A familiar that follows Isaac around shooting blood tears.
Grants 1 heart container and increases tears, but decreases shot speed.
Grants one soul heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears.
+5 range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room.
Adds an extra life; upon death, it respawns Isaac as Black Judas with only two black hearts.
Spawns an orbiting eye familiar that fires tears every 2 seconds.
A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage.
While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
Missing Page 2
Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.
When Isaac is hit, 1 point of an item's charge is filled.
Doubles damage, halves tears stat, and greatly reduces shot speed.
An angel familiar which follows Isaac and fires homing tears which deal 10 damage at -25% shot speed and a reduced fire rate.
Grants a unlimited range piercing laser with random rate of fire that does not replace tears. The laser might occasionally fire with the effect of a random item or trinket, such as Hook Worm, Spoon Bender or Tiny Planet.
When hit, summons a white attack fly similar to Distant Admiration for the current room.
Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
All types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.
Gives Isaac 99 coins. Can be found multiple times in a single playthrough.