Key Piece 2
Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
An Angel Room door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Follows Isaac and automatically fires at enemies in its reach.
Grants a familiar that transforms into another random familiar every 10 seconds.
Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.
Gives one extra pickup (1+1 Free version) of Red Hearts, pennies, bombs, and keys. Does not work with blue, black, and half red hearts, nickels, and dimes.
Circle of Protection
Surrounds Isaac with a large white halo around him that pulsates. With each pulse, the halo deals contact damage to enemies equal to Isaac's damage. Each pulse also converts any enemy shots touching the ring into friendly purple homing tears.
Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
Converts all bad pills into good pills, spawns one pill pickup and restores health. Identifies all pills upon pickup.
Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short lasting pool of green creep on the ground.
A white orbiting fly which deals 3 contact damage per tick to enemies. This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone.
While firing, Isaac gains a green aura that poisons nearby enemies.
Increases damage by 1 and range by 5 for tears fired from the left eye.
Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.