Item: Tammy's Head
Sets a big red target on the ground (similar to the Epic Fetus item) which can be controlled with tear controls. After 6 seconds or by pressing space again, a huge explosive missile hits it, which damages all enemies caught in its blast radius.
Spawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in The Dark Room.
For 1 coin, damages all enemies in the room.
Spawns 2-4 blue flies to damage enemies.
When used, copies the effect of the pill Isaac is currently holding without consuming it. Does not copy the effects of cards or runes.
Bombs you place explode only when you use this item. Gives 5 bombs.
Throws out a blue flame that can pass over gaps (but not through rocks). The flame damages anything in its path.
Transforms Isaac into another random character.
Upon activation, enemies and their projectiles are slowed down for a short duration.
Book of Shadows
Upon use, creates a protective shield nullifying all types of damage for 10 seconds.
Upon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed.
When used, Mom's Box will drop a random trinket on the ground. While held, increases luck by 1 and doubles the effects of trinkets.
Summons a random familiar for the current room. Can summon familiars not yet unlocked.
Teleports Isaac to either the Secret Room, Super Secret Room, Treasure Room, or I AM ERROR.
Throws a short-range boomerang which does a bit of damage and has a high chance to stun the enemy for 2 seconds. Can also be used to grab pickups.
Shoots 10 tears in a circle around Isaac, which retain the damage, shot speed, and special effects (such as poison) of Isaac's tears.
Telepathy for Dummies
Upon activation, grants homing tears for the current room.
Breath of Life
Grants a brief moment of invincibility when the charge bar hits zero. If spacebar is held for an additional second after hitting zero, Isaac will take damage.
Upon use, sacrifices up to 2 familiars and spawns an item from the Devil Room Pool for each familiar sacrificed.