Crack the Sky
Summons multiple beams of light in random locations around the room, dealing a large amount of damage to any enemy that touches them.
Upon activation, enemies and their projectiles are slowed down for a short duration.
Upon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed.
Upon use, Isaac fires a laser similar to the one used by Mega Satan. This laser deals massive damage, lasts for approximately 15 seconds, and persists between rooms. Isaac is pushed backwards by the force of the laser while it is active.
Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room.
Teleports you to a random room on the level.
Upon use, deals one heart of damage to Isaac and grants +1.2 damage for the current room.
Damages all enemies in the room and slows them and their projectiles down.
Isaac releases bad gas, poisoning any enemy in close vicinity.
For 1 coin, damages all enemies in the room.
Upon use, Isaac farts, charming all nearby enemies.
Transforms Isaac into another random character.
Summons a random familiar for the current room. Can summon familiars not yet unlocked.
Upon use, spawns certain pickups or itemsdepending on the floor it is used on. Single-use.
Reveals the map (except the Super Secret Room) and drops a random Tarot Card or soul heart.
Upon use, spawns a sprinkler that rotates and fires tears.
Bombs you place explode only when you use this item. Gives 5 bombs.
Book of Secrets
Upon use, gives the effect of Treasure Map, The Compass, or Blue Map for the duration of the current floor.