Item: The Battery
Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.
Spawns allied blue spiders from killed enemies.
Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
+5 bombs. Bombs stick to enemies and spawn 2-4 blue spiders if they kill an enemy.
Gives Isaac's tears a boomerang effect, and increases range and shot speed.
A familiar that follows Isaac and blocks tears. If a tear hits Farting Baby, there is a high chance for it to fart, which will either knock back, poison, or charm all nearby enemies.
A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.
A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.
Reveals all special rooms (except secret rooms of any kind).
Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.
After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
Upon dying, resurrect as Revived Lazarus with one heart container and Anemic item.
An angel familiar which follows Isaac and fires homing tears which deal 10 damage at -25% shot speed and a reduced fire rate.
+1 Luck. Increases chance of winning Shell Game Beggar. (Independent of luck stat)
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
A glass of milk follows Isaac and spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the rest of the room.
Every tear has a small shield which will allow it to block one enemy projectile.