Item: The Body
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
Reduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.
Eye of Belial
Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
Increases damage and increases the chance for a Devil or Angel Room to appear.
The Black Bean
When taking damage, Isaac farts, causing poison damage to all enemies in range.
Has a chance to drop a random pickup when Isaac takes damage.
Chaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor.
Gives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
Guppy's Hair Ball
Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
8 Inch Nails
+1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.
Isaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms.
Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Grants charged tears that deal greater damage when fully charged.
Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.
1-3 Blue flies randomly spawn every time Isaac gets hit.
Increases Luck by 1, grants 1 Soul Heart and spawns 2 Keys.
Key Piece 2
Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.