Item: The Boomerang
Damages all enemies in the room and slows them and their projectiles down.
Shoop Da Whoop!
Fires a laser from Isaac's mouth.
Removes one red heart container in exchange for gaining 3 Soul Hearts.
Damages all enemies in the room, but deals a heart of damage to Isaac with each use.
The Book of Sin
Spawns a random pickup, pill, card, or trinket.
Spawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in The Dark Room.
Upon use, for the next two seconds, any enemy shots that come near Isaac are held in place. After the charge is depleted, they are fired back as tears.
Reveals the map (except the Super Secret Room) and drops a random Tarot Card or soul heart.
Transforms Isaac into another random character.
Bob's Rotten Head
Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.
Upon use, spawns a sprinkler that rotates and fires tears.
Upon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.
When used, reduces Isaac's health to half a heart (including soul and black hearts) and fires one large piercing spectral tear that does a lot of damage. The damage done by Glass Cannon scales with Isaac's damage (at base damage it does 45 damage).
When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head.
The Pinking Shears
Separates Isaac's head and body for the current room. Isaac's head, which now has flight, will be under the player's control, while his body will seek out enemies to attack by contact damage.
Book of Shadows
Upon use, creates a protective shield nullifying all types of damage for 10 seconds.
Freezes all enemies until a fire button is pressed.
Summons a controllable ghost that can perform various tasks depending on what it targets.