Item: The Ladder
Doubles damage, halves tears stat, and greatly reduces shot speed.
Blood of the Martyr
Increases Damage by 1, and turns Isaac's tears into blood tears.
Tears bounce off walls, enemies, and environmental objects.
Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Reveals type of adjacent rooms, including location for secret rooms and super secret rooms.
Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.
Spawns a beggar familiar which floats around the room and picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo chases enemies slowly, dealing contact damage.
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Increases range and shot speed, while adding 1 Black Heart.
Increases damage and range while reducing tears and shot speed. Grants homing tears and tears gain a damaging halo.
Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
A familiar that drops a Little Battery every 4 rooms. Has a small chance to freeze all enemies in the room when hit.
Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.
Circle of Protection
Surrounds Isaac with a large white halo around him that pulsates. With each pulse, the halo deals contact damage to enemies equal to Isaac's damage. Each pulse also converts any enemy shots touching the ring into friendly purple homing tears.
After taking damage a certain amount of times, a permanent demonic familiar spawns.
Ball of Tar
Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Increases Damage by 1 and adds a chance to shoot fear tears.