Item: The Mark
A familiar that drops a Little Battery every 4 rooms. Has a small chance to freeze all enemies in the room when hit.
Drops a random trinket. Grants a second trinket slot.
Isaac will now fire tears automatically directed at a red target on the ground which is controlled by the player. This allows for a full 360 degree tear firing radius. Can be overridden by other tear modifiers such as Mom's Knife or Brimstone.
Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Reveals type of adjacent rooms, including location for secret rooms and super secret rooms.
Spawns a familiar that will follow Isaac's movements on a 2.5 second delay. Tears that pass through the baby will be doubled and increase in speed.
Makes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.
Follows Isaac and automatically fires at enemies in its reach.
Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Two items spawn in every Treasure Room. Only one can be taken; the other will disappear.
Spear of Destiny
In addition to tears, Isaac now holds a spear in front of him which deals damage equal to 2 times his tear damage, and occasionally inflicts fear. The spear cannot be thrown, but deals damage while it is in contact with an enemy.
Grants poison tears, which deal damage over time when inflicted.
Glyph of Balance
Grants 2 soul hearts and modifies drops from Champion Monsters based on certain conditions.
Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.
Grants Isaac one red heart container and fully restores Isaac's health.
A glass of milk follows Isaac and spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the rest of the room.
Gives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy.
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.