Item: The Mulligan
Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
Causes Isaac's activated item to activate twice on each use.
Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
Connects Isaac's tears with electricity that can damage enemies.
Spawns a beggar familiar which floats around the room and picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo chases enemies slowly, dealing contact damage.
Two items spawn in every Treasure Room. Only one can be taken; the other will disappear.
Gives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny.
Grants four soul hearts and fully restores Isaac's red health.
+5 range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room.
Lord of the Pit
Grants flight and increases speed.
Grants a soul heart. Adds a chance to block enemy shots.
Bucket of Lard
Grants two empty heart containers and heals Isaac by half a heart, but decreases speed by 0.2.
Gives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode.
Spirit of the Night
Grants spectral tears and flight.
Increases damage by 1, range by 5.25, and tear height by 0.5.
A familiar that damages enemies by chasing them as well as inducing the fear effect.
Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.
Increases damage by a flat 0.1 and grants a soul heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.
Spawns a familiar that slowly charges forward and damages enemies in its path.