Item: The Parasite
Grants Isaac one red heart container and fully restores Isaac's health.
Adds a chance to fire a booger which sticks to enemies and poisons them.
Increases damage. Adds a chance to fire acidic tears which can destroy obstacles.
Key Piece 1
Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier.
Grants a soul heart. Adds a chance to block enemy shots.
A familiar that charges forward and deals touch damage to any enemies in its path.
A trail of blue creep is left behind Isaac, which damages enemies.
Isaac gains a shield that protects him from enemy shots.
When Isaac is hit, 1 point of an item's charge is filled.
Adds one heart container and drops a random trinket.
Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
A familiar who will drop a half red heart every 2 rooms.
A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.