Item: The Polaroid

Spawns a Mysterious Paper, increases tears, and grants a bone heart.

Spawns a finger familiar that points at enemies, dealing constant damage.

Adds a chance to shoot poison tears, dealing damage over time when inflicted.

A familiar that spawns blue flies.

Adds one heart container and drops a random trinket.

Daddy Long Legs' shadow follows Isaac and stomps on enemies.

Increases damage by 1 and range by 5 for tears fired from the left eye.

Causes Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic.

A familiar that damages enemies by chasing them as well as inducing the fear effect.

Gives one heart container and doubles the healing provided by red hearts.

+1.7 tears, +0.3 speed, reduces damage.

An orbital angel which does 7 contact damage per tick and blocks enemy shots. Upon blocking 10 shots in a room it drops an eternal heart.

Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.

When taking damage, Isaac farts, causing poison damage to all enemies in range.

Isaac is followed by a small bag that drops a coin every 2 rooms.

A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.

Once per room, when Isaac is reduced to his last half red Heart, the aura around his head temporarily vanishes and he is granted one Soul Heart.

Removed in Afterbirth: Automatically inflicts slow to all enemies in every room.
Added in Afterbirth: Upon taking damage, inflicts slow to all enemies for the current room.

Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.

Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.