Item: The Poop
Hurts Isaac without depleting health, activating any items that trigger upon taking damage.
Isaac holds the axe above his head for as long as the spacebar button is held (or until he leaves the room). While holding the axe, Isaac can break any rock he touches, but cannot attack or pick up other items.
Deploys a decoy Isaac that eventually explodes with an increased blast radius.
Creates an explosion in the same area as Isaac, dealing half a heart of damage to him and also damaging all enemies caught in the blast radius.
Book of Revelations
Adds 1 soul heart, increases the chance for a Devilor Angel Room to appear, and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom).
Upon use, spawns a random item from the current room's item pool, with a chance to spawn A Lump of Coal or The Poop instead.
Can be used to place an orange portal and a blue portal. Upon entering a portal, Isaac is teleported to the other portal.
Book of Shadows
Upon use, creates a protective shield nullifying all types of damage for 10 seconds.
Damages all enemies in the room and slows them and their projectiles down.
Upon activation, enemies and their projectiles are slowed down for a short duration.
Throws a short-range boomerang which does a bit of damage and has a high chance to stun the enemy for 2 seconds. Can also be used to grab pickups.
The Book of Sin
Spawns a random pickup, pill, card, or trinket.
Telepathy for Dummies
Upon activation, grants homing tears for the current room.
Upon use, inflicts fear to all enemies in the room for 5 seconds.
Spawns a stationary fly familiar that fires tears at nearby enemies.
Shoots 8 tears around Isaac, which retain the damage, shot speed, and special effects of his tears. Each tear shot by Isaac increases item charge by one.
Upon use, Isaac fires a laser similar to the one used by Mega Satan. This laser deals massive damage, lasts for approximately 15 seconds, and persists between rooms. Isaac is pushed backwards by the force of the laser while it is active.