Item: The Relic

+1.7 tears, +0.3 speed, reduces damage.

Grants flight and one heart container.

Spawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep.

Chaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor.

Daddy Long Legs' shadow follows Isaac and stomps on enemies.

Grants flight and increases speed.

Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes.

Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies.

Spawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.

A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.

Tears shrink and do much less damage, but fire in very rapid succession.

Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, it stops moving.

A red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.

Adds 25 to Isaac's coin count, capping at 99.

Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short lasting pool of green creep on the ground.

Reveals and opens all Secret Room and Super Secret Room entrances.

Spawns a Mysterious Paper, increases tears, and grants a bone heart.

Spawns a friendly familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one.

Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.

Adds 3 heart containers.