Item: The Relic
+1.7 tears, +0.3 speed, reduces damage.
Spawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep.
Chaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor.
Daddy Long Legs' shadow follows Isaac and stomps on enemies.
Lord of the Pit
Grants flight and increases speed.
Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes.
Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies.
Spawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.
A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.
Tears shrink and do much less damage, but fire in very rapid succession.
Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, it stops moving.
A red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Adds 25 to Isaac's coin count, capping at 99.
Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short lasting pool of green creep on the ground.
Reveals and opens all Secret Room and Super Secret Room entrances.
Spawns a Mysterious Paper, increases tears, and grants a bone heart.
Spawns a friendly familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one.
Contract From Below
Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.