Item: The Wafer
1-3 Blue flies randomly spawn every time Isaac gets hit.
Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.
Head of the Keeper
Isaac's tears become coins and now have a chance to drop pennies on the floor upon successfully hitting an enemy.
Grants a chance of converting any red hearts pickups into soul hearts instead.
Gives Isaac a Gurdy familiar that will charge around the room dealing contact damage to enemies. Lil Gurdy is charged by holding down a fire button and letting go. The longer the button is held, the faster Lil Gurdy will fling itself across the screen. Lil Gurdy can pass over objects and obstacles in the room.
+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.
Glyph of Balance
Grants 2 soul hearts and modifies drops from Champion Monsters based on certain conditions.
Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
Spawns a friendly familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one.
Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.
Spawns a familiar that follows Isaac around and fires spectral tears.
Grants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.
Causes shops to instantly restock their items when they are bought. Granted by default for every character in Greed Mode.
Increases Damage by 1 and adds a chance to shoot fear tears.
Increases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.
Reveals and opens all Secret Room and Super Secret Room entrances.
???'s Only Friend
Summons a big attack fly that can be controlled with the shooting direction-keys.
Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.