Item: Thunder Thighs
Grants poison tears, which deal damage over time when inflicted.
Gives one heart container and doubles the healing provided by red hearts.
Isaac gains a shield that protects him from enemy shots.
Spawns a blue attack fly that orbits a long distance from Isaac.
Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier.
Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the size of the ring.
Grants 7 bombs and allows bombs to be placed rapidly.
Spawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Allows Isaac to carry two cards or pills (or a combination of both) at the same time.
Greatly increases the chance to find sacks.
Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
A blue fly familiar follows Isaac's movements on a 3 second delay. Papa Fly will fire tears at nearby enemies.
Eye of Belial
Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
The Inner Eye
Grants triple shot but decreases tears.
Spawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.
Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short lasting pool of green creep on the ground.