Item: Tiny Planet
A familiar who will drop a half red heart every 2 rooms.
Spawns a bone familiar that can be aimed with the fire buttons and does contact damage.
Increases damage and range while reducing tears and shot speed. Grants homing tears and tears gain a damaging halo.
Key Piece 1
Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
Spawns a finger familiar that points at enemies, dealing constant damage.
A demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.
Tears fired from left eye do increased damage.
A familiar that follows Isaac and blocks tears. If a tear hits Farting Baby, there is a high chance for it to fart, which will either knock back, poison, or charm all nearby enemies.
Increases damage by 1 and range by 5 for tears fired from the left eye.
Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.
Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.
Sets your key count to the maximum of 99.
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Isaac can hold 2 pills at once and all cards are replaced by pills.
A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.
Isaac can hold 2 cards at once and all pills are replaced by cards.