Item: Tough Love
Buddy in a Box
Grants a familiar with a random tear effect. The familiar is randomized at the start of each floor.
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Lord of the Pit
Grants flight and increases speed.
There will be 2 items available to choose from after defeating a boss. Choosing 1 item causes the other to disappear.
Causes shops to instantly restock their items when they are bought. Granted by default for every character in Greed Mode.
Sets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again.
A bag that follows Isaac and drops a random rune every 3 rooms.
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
A familiar who will drop a half red heart every 2 rooms.
Gives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
Zodiac will give Isaac a random zodiac item effect that changes after every floor.
Spawns a fly familiar that orbits around a random enemy and deals 5 damage per tick to enemies it comes in contact with.
Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.