Item: Virgo

Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Boom Fliesdamaging enemies it passes through.

Isaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms.

Grants Isaac one full red heart container.

Sets your key count to the maximum of 99.

After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.

Grants one full red heart container.

Isaac can hold 2 pills at once and all cards are replaced by pills.

Isaac gains a shield that protects him from enemy shots.

Grants 2 Heart Containers and completely restores health.

Increases range and shot height.

Tears bounce off the floor. Tears that hit an enemy after bouncing deal splash damage to all nearby enemies for 25% of Isaac's tear damage.

Increases Luck by 1, grants 1 Soul Heart and spawns 2 Keys.

Increases range and shot speed, while adding 1 Black Heart.

Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.

An orbital angel which does 7 contact damage per tick and blocks enemy shots. Upon blocking 10 shots in a room it drops an eternal heart.

Increases all stats and enlargens Isaac.

Grants 10 bombs.

A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.

Whenever Isaac takes damage, a black ring briefly appears around Isaac, dealing damage to all nearby enemies.

Isaac's tears gain a random effect that changes every shot.