Item: Yum Heart
Shoots 8 tears around Isaac, which retain the damage, shot speed, and special effects of his tears. Each tear shot by Isaac increases item charge by one.
Upon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed.
Shoop Da Whoop!
Fires a laser from Isaac's mouth.
While held, causes multiple Mom's Foots to come down and stomp on Isaac. One of two parts necessary to create Mom's Shovel.
Damages all enemies in the room significantly.
Spawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in The Dark Room.
Bob's Rotten Head
Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.
Isaac holds the axe above his head for as long as the spacebar button is held (or until he leaves the room). While holding the axe, Isaac can break any rock he touches, but cannot attack or pick up other items.
Changes all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.
Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room.
Summons a controllable ghost that can perform various tasks depending on what it targets.
Dead Sea Scrolls
Triggers the effect of a random activated item from a list of possible options (not every activated item is included).
When used, places an explosive TNT barrel that can be pushed and used to destroy rocks or damage enemies. If used a second time in the same room while the previous TNT barrel is still intact, it will remotely explode the TNT.
Grants a random item effect for the current room.
Reveals the map (except the Super Secret Room) and drops a random Tarot Card or soul heart.
Spawns a stationary fly familiar that fires tears at nearby enemies.